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KMID : 0379119820100040155
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Korean Journal of Mycology
1982 Volume.10 No. 4 p.155 ~ p.163
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Studies on Constituents of Higher Fungi of Korea (35)
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Abstract
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To find antitumor components, a protein-bound polysaccharide fraction was obtained by extracting with hot water and precipitating with ethanol from the carpophores and the cultured mycelia of Laccaria laccata. The fraction was examined for antitumor activity against sarcoma 180 implanted in mice. The component extracted from the carpophores showed 75% and 60% tumor inhibition ratios in the doses of 20㎎ and 50㎎/㎏/day, respectively. The protein-bound polysaccharide fraction of the cultured mycelia of L. laccata also showed 57.8% tumor inhibition ratio in the dose of 20㎎/㎏/day. The chemical analysis of the protein-bound polysaccharide fraction showed that it contained a polysaccharide and a protein. The hydrolysates of the polysaccharide moiety contained six and one unknown monosaccharides. Fourteen amino acids were identified in the hydrolysates of the protein moiety.
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KEYWORD
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